产品货号：
Z16378
中文名称：
EPAS1抗体
英文名称：
Anti-EPAS1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-EPAS1 Antibody |
| 指标别名 | bHLHe73;ECYT4;EPAS 1;EPAS1;HIF 1 alpha like factor;HIF 2 alpha;HIF2 alpha;HIF2A;HIF-2A;HIF2α;HIF-2α;HLF;Member of PAS protein 2;MOP2;PASD2 |
| 克隆性 | Polyclonal |
| 检验物种 | rat |
| 应用范围 | WB,IHC |
| 基因名称 | EPAS1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at N-terminus of rat HIF-2-alpha(202-240aa YNNCPPHSSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLD). |
| 实际分子量 | 96KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | HIF-2 alpha is also designated EPAS1 whose gene is mapped to 2p21-p16.The predicted mouse protein is 88% identical to human EPAS1.The human EPAS1 gene contains 15 exons and spans at least 120kb.The positions of the introns within the genomic region encoding the N-terminal bHLH-PAS domains of EPAS1 and AHR are similar,suggesting that the 5-prime ends of the 2 genes may have arisen from a gene duplication event1.Moreover,the predicted protein shares 48% sequence identity with HIF1-alpha,a bHLH-PAS transcription factor that induces EPO gene expression in cultured cells in response to hypoxia.Like HIF1A,EPAS1 binds to and activates transcription from the HIF1A response element derived from the 3-prime flanking region of the EPO gene.EPAS1 is predominantly expressed in highly vascularized tissues of adult humans and in endothelial cells of the mouse adult and embryo.Furthermore,EPAS1 may represent an important regulator of vascularization,perhaps involving the regulation of endothelial cell gene expression in response to hypoxia2.HIF2A is expressed at relatively higher levels in villus sections of placenta and in lung samples compared with other tissues examined3.In addition,The variation in EPAS1 influences the relative contribution of aerobic and anaerobic metabolism and hence the maximum sustainable metabolic power for a given event duration4. |
| Uniprot ID | Q9JHS1 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | endothelial PAS domain protein 1 |
| 蛋白名全称 | Endothelial PAS domain-containing protein 1(EPAS-1) |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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